β-MANNANASE is an endo-mannanase preparation designed to hydrolyze the mannan, gluco-mannan and galacto-mannan in plant feed ingredients, releasing and making available the trapped energy and proteins. Through the submerged liquid fermentation production process as well as the comprehensive application of after-treatment technologies, Because of the high enzyme activity, the various preparations as well as their high efficiency these products can meet different needs. β-MANNANASE allows maximized use of nutrient dense, lower priced plant feed ingredients without the negative effects previously encountered.
The Anti-Nutrition Effects of β-Mannans:
β-Mannans are linear polysaccharides composed of repeating D-mannose units with β-1,4 bonds and D-galactose units. The contents of mannan in the common used feed ingredients was shown in table 1. Soybean meal, coconut meal, and palm kernel meal contain high percentage of β-mannan, a highly anti-nutritive fiber which inhibits live performance in broilers. Even if there is a little amount of β-mannan in feed materials, it will cause a very bad effect in blocking absorption of nutrients for livestock and poultry (mainly for monogastric animals). Its anti-nutrition effect can be summarized as the following four aspects:
1. Reduce the digestion and absorption of nutrients, affect diet conversion rate and animal performance.
2. Interaction with microorganism system in the back-end alimentary canal thus result in anaerobic fermentation and produce a large amount of clostridium which will produce mycotoxin and inhibit animal growth.
3. β-Mannans are highly viscous and may have adverse effects on the digestive systems. Viscosity reduction has been suggested as a primary reason for improved performance with certain endolytic enzymes used in association with barley-based highly viscous cereals.
4. β-Mannans crossing the intestinal mucosa are potent stimulators of the innate immune system, resulting in increased proliferation of macrophages and monocytes and resultant cytokine production. These result in exacerbated disease symptoms and reduced nutrient utilization.
The Mechanism of β-MANNANASE:
β-MANNANASE can degrade β-mannan, eliminate anti-nutrition effect of β-mannan, decrease digesta viscosity and destroy the structure cell wall of the botanical feed, increase the feed digestibility and, improve the secretion of insulin and the production of insulin-like growth factor (IGF-I) to improve carbohydrate metabolism for better energy utilization. IGF-I is the real growth regulatory factor of livestock and poultry and it mediates the growth effect of the growth hormone (GH). Acting on the growth organization and stimulating the amino acid utilization of the cells, it helps the protein synthesis, eliminates the decomposition of protein and helps the protein net growth of animals.
β-MANNANASE can also degrade mannan into mannan-oligosaccharide, which is beneficial for intestinal microorganism population and for the host; moreover, the mannan-oligosaccharide can distinguish, bond to the pathogenic microorganism and then eliminate them, it can regulate body immune thus improve the performance of the livestock and poultry. Mannan-oligosaccharide can competitively combines with certain pathogenic bacteria in the animal bodies and improve the proliferation of beneficial bacteria, by these, reduce the contact between the pathogenic bacteria and epithelial cells of the intestinal mucosa, greatly reduce the incidence rate and help the animal bodies grow healthy, thus achieve the goal of disease prophylaxis, resistance and finally cure.
The mode of action of β-MANNANASE is complex, but is probably related to:
1.Its effect on insulin secretion, glucose absorption and energy metabolism.
2.Its effect on viscosity in the gut;
3.Reduced stimulation of the innate immune system, resulting in a reduced expenditure of energy for non-productive purposes.
The Function of β-MANNANASE:
(i) Eliminate the effects of anti-nutritional factors of mannan to increase nutrient digestibility; more efficient utilization of plant feed ingredients
(ii) Improvement in the uniformity of body weights
(iii) Reduction in mortality rates and fecal production
(iv) Under stress condition, β-mannanase can greatly improve the growth performance of livestock and poultry.
(v)Increase in breast meat yield
(vi) Adsorb mycotoxin. Studies show that mannan-oligosaccharide, degraded from mannan, can eliminate harmful effects of mycotoxin on livestock and poultry by physical adsorption or direct integration.
β-MANNANASE is both better resists the pelleting process and delivers the gastric stability needed to work more effectively in the key portions of the GI tract. It has an excellent heat tolerant ability; enzyme activity loss rate is more than 80% under 85℃ pelleting condition. β-MANNANASE also opposes a stable performance
